SMAD3
Gene Information
- Official Symbol: SMAD3
- Official Name: SMAD family member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 4088
- UniProt: P84022
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| MH1 |
| MH2 |
GO Terms
| negative regulation of lung blood pressure |
| mineralocorticoid receptor binding |
| heteromeric SMAD protein complex |
| positive regulation of transforming growth factor beta3 production |
| regulation of transforming growth factor beta3 production |
| activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| regulation of lung blood pressure |
| evasion or tolerance of host defenses by virus |
| positive regulation of extracellular matrix assembly |
| avoidance of host defenses |
| evasion or tolerance of defenses of other organism involved in symbiotic interaction |
| avoidance of defenses of other organism involved in symbiotic interaction |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| evasion or tolerance of host defenses |
| positive regulation of alkaline phosphatase activity |
| negative regulation of cardiac muscle hypertrophy in response to stress |
| negative regulation of cardiac muscle adaptation |
| response to host |
| response to defenses of other organism involved in symbiotic interaction |
| SMAD protein complex assembly |
| SMAD protein complex |
| transdifferentiation |
| response to host defenses |
| DEAD/H-box RNA helicase binding |
| regulation of transforming growth factor beta2 production |
| primary miRNA binding |
| regulation of extracellular matrix assembly |
| primary miRNA processing |
| embryonic foregut morphogenesis |
| negative regulation of osteoblast proliferation |
| regulation of cardiac muscle adaptation |
| regulation of cardiac muscle hypertrophy in response to stress |
| regulation of alkaline phosphatase activity |
| paraxial mesoderm morphogenesis |
| foregut morphogenesis |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| negative regulation of muscle adaptation |
| co-SMAD binding |
| nodal signaling pathway |
| negative regulation of cytosolic calcium ion concentration |
| enhancer binding |
| glucocorticoid receptor binding |
| regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| paraxial mesoderm development |
| positive regulation of transforming growth factor beta production |
| osteoblast development |
| signal transduction involved in regulation of gene expression |
| pericardium development |
| positive regulation of chondrocyte differentiation |
| positive regulation of extracellular matrix organization |
| thyroid gland development |
| regulation of osteoblast proliferation |
| R-SMAD binding |
| activin receptor signaling pathway |
| adrenal gland development |
| positive regulation of focal adhesion assembly |
| positive regulation of positive chemotaxis |
| bHLH transcription factor binding |
| negative regulation of cardiac muscle hypertrophy |
| regulation of positive chemotaxis |
| lens fiber cell differentiation |
| negative regulation of muscle hypertrophy |
| production of miRNAs involved in gene silencing by miRNA |
| proximal promoter sequence-specific DNA binding |
| positive regulation of pri-miRNA transcription by RNA polymerase II |
| positive regulation of adherens junction organization |
| modulation by virus of host morphology or physiology |
| dsRNA processing |
| positive regulation of cartilage development |
| positive regulation of cell junction assembly |
| production of small RNA involved in gene silencing by RNA |
| positive regulation of phosphatase activity |
| regulation of transforming growth factor beta production |
| positive regulation of protein import into nucleus |
| regulation of extracellular matrix organization |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of bone mineralization |
| positive regulation of protein import |
| positive regulation of nitric oxide metabolic process |
| modification by symbiont of host morphology or physiology |
| regulation of pri-miRNA transcription by RNA polymerase II |
| transforming growth factor beta receptor binding |
| negative regulation of osteoblast differentiation |
| embryonic cranial skeleton morphogenesis |
| nuclear inner membrane |
| negative regulation of fat cell differentiation |
| gene silencing by miRNA |
| positive regulation of biomineral tissue development |
| positive regulation of biomineralization |
| positive regulation of epithelial to mesenchymal transition |
| digestive tract morphogenesis |
| phosphatase binding |
| positive regulation of reactive oxygen species biosynthetic process |
| mesenchyme morphogenesis |
| positive regulation of cell-matrix adhesion |
| regulation of chondrocyte differentiation |
| positive regulation of stress fiber assembly |
| positive regulation of interleukin-1 beta production |
| RNA polymerase II activating transcription factor binding |
| regulation of protein import into nucleus |
| regulation of nitric oxide biosynthetic process |
| regulation of cardiac muscle hypertrophy |
| SMAD protein signal transduction |
| posttranscriptional gene silencing by RNA |
| positive regulation of dephosphorylation |
| regulation of protein import |
| positive regulation of interleukin-1 production |
| posttranscriptional gene silencing |
| regulation of muscle hypertrophy |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| heart looping |
| positive regulation of actin filament bundle assembly |
| embryonic pattern specification |
| positive regulation of nucleocytoplasmic transport |
| collagen binding |
| somitogenesis |
| cranial skeletal system development |
| determination of heart left/right asymmetry |
| embryonic heart tube morphogenesis |
| regulation of adherens junction organization |
| mesoderm formation |
| mesoderm morphogenesis |
| regulation of cartilage development |
| negative regulation of wound healing |
| chromatin DNA binding |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| endoderm development |
| negative regulation of ossification |
| positive regulation of protein localization to nucleus |
| regulation of bone mineralization |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| embryonic heart tube development |
| lens development in camera-type eye |
| regulation of stress fiber assembly |
| ubiquitin binding |
| regulation of interleukin-1 beta production |
| somite development |
| transcription coregulator activity |
| beta-catenin binding |
| regulation of epithelial to mesenchymal transition |
| positive regulation of ossification |
| regulation of muscle adaptation |
| ureteric bud development |
| regulation of reactive oxygen species biosynthetic process |
| negative regulation of response to wounding |
| gene silencing by RNA |
| mesonephric epithelium development |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| mesonephric tubule development |
| regulation of actomyosin structure organization |
| regulation of cell junction assembly |
| mesonephros development |
| regulation of actin filament bundle assembly |
| regulation of biomineral tissue development |
| regulation of biomineralization |
| embryonic skeletal system morphogenesis |
| regulation of interleukin-1 production |
| segmentation |
| positive regulation of reactive oxygen species metabolic process |
| extrinsic apoptotic signaling pathway |
| transforming growth factor beta receptor signaling pathway |
| regulation of nucleocytoplasmic transport |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| formation of primary germ layer |
| regulation of osteoblast differentiation |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cell-matrix adhesion |
| regulation of cellular response to transforming growth factor beta stimulus |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of protein localization to nucleus |
| determination of left/right symmetry |
| endocrine system development |
| positive regulation of cell-substrate adhesion |
| regulation of fat cell differentiation |
| determination of bilateral symmetry |
| mesoderm development |
| specification of symmetry |
| liver development |
| osteoblast differentiation |
| embryonic skeletal system development |
| hepaticobiliary system development |
| kidney epithelium development |
| digestive tract development |
| regulation of striated muscle tissue development |
| negative regulation of protein catabolic process |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| positive regulation of chemotaxis |
| negative regulation of inflammatory response |
| cell-cell junction organization |
| regulation of wound healing |
| digestive system development |
| positive regulation of canonical Wnt signaling pathway |
| cell cycle arrest |
| negative regulation of cellular response to growth factor stimulus |
| positive regulation of cysteine-type endopeptidase activity |
| gene silencing |
| positive regulation of intracellular protein transport |
| cellular response to transforming growth factor beta stimulus |
| modification of morphology or physiology of other organism |
| interaction with host |
| gastrulation |
| response to transforming growth factor beta |
| regulation of response to wounding |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| regulation of phosphatase activity |
| positive regulation of Wnt signaling pathway |
| protein stabilization |
| regulation of reactive oxygen species metabolic process |
| regulation of blood pressure |
| negative regulation of cell growth |
| regulation of ossification |
| positive regulation of peptidase activity |
| positive regulation of supramolecular fiber organization |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| receptor complex |
| transcription factor complex |
| negative regulation of defense response |
| positive regulation of intracellular transport |
| regulation of cell-substrate adhesion |
| regulation of dephosphorylation |
| regulation of chemotaxis |
| cell junction organization |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| anterior/posterior pattern specification |
| transcription regulatory region DNA binding |
| positive regulation of cytoskeleton organization |
| mesenchyme development |
| regulation of intracellular protein transport |
| regulation of muscle system process |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| T cell activation |
| regulation of gene expression, epigenetic |
| nuclear chromatin |
| skeletal system morphogenesis |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of growth |
| heart morphogenesis |
| regulation of actin filament organization |
| positive regulation of DNA-binding transcription factor activity |
| ossification |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| regulation of canonical Wnt signaling pathway |
| protein deubiquitination |
| apoptotic signaling pathway |
| renal system development |
| regulation of protein stability |
| embryonic organ morphogenesis |
| ubiquitin protein ligase binding |
| protein modification by small protein removal |
| negative regulation of mitotic cell cycle |
| epithelial tube morphogenesis |
| negative regulation of catabolic process |
| camera-type eye development |
| urogenital system development |
| positive regulation of cellular protein localization |
| regulation of cytosolic calcium ion concentration |
| regionalization |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| regulation of inflammatory response |
| response to hypoxia |
| regulation of actin cytoskeleton organization |
| regulation of intracellular transport |
| regulation of supramolecular fiber organization |
| regulation of neurotransmitter levels |
| positive regulation of proteolysis |
| response to decreased oxygen levels |
| eye development |
| visual system development |
| regulation of Wnt signaling pathway |
| negative regulation of response to external stimulus |
| sensory system development |
| regulation of binding |
| in utero embryonic development |
| response to oxygen levels |
| lymphocyte activation |
| regulation of protein catabolic process |
| ncRNA processing |
| regulation of actin filament-based process |
| developmental growth |
| blood circulation |
| growth |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| positive regulation of cell adhesion |
| gland development |
| regulation of endopeptidase activity |
| regulation of cell growth |
| sequence-specific DNA binding |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| cellular calcium ion homeostasis |
| regulation of peptidase activity |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| calcium ion homeostasis |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| cellular divalent inorganic cation homeostasis |
| ncRNA metabolic process |
| wound healing |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| skeletal system development |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| posttranscriptional regulation of gene expression |
| heart development |
| response to growth factor |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| sensory organ development |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| negative regulation of cell cycle |
| regulation of system process |
| positive regulation of response to external stimulus |
| positive regulation of organelle organization |
| metal ion homeostasis |
| regulation of mitotic cell cycle |
| cellular cation homeostasis |
| chordate embryonic development |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| immune system development |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of growth |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| viral process |
| regulation of protein transport |
| cation homeostasis |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| regulation of proteolysis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of defense response |
| positive regulation of hydrolase activity |
| symbiotic process |
| ion homeostasis |
| interspecies interaction between organisms |
| zinc ion binding |
| cellular protein-containing complex assembly |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| RNA processing |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| regulation of cellular localization |
| apoptotic process |
| leukocyte activation |
| negative regulation of developmental process |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| embryo development |
| regulation of locomotion |
| protein modification by small protein conjugation or removal |
| positive regulation of transport |
| regulation of catabolic process |
| negative regulation of cell death |
| regulation of cellular component movement |
| cell cycle process |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| programmed cell death |
| identical protein binding |
| cell activation |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| regulation of immune response |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| WNT3A 44ng/ml R08 exp537 | -2.15 |
| FK-506 30μM R07 exp359 | 1.77 |
| BS-181 20μM R08 exp461 | 2.24 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6139
- Expression level (log2 read counts): 2.59
Expression Distribution
SMAD3 Expression in NALM6 Cells: 2.59
