SRP54

Entrez Summary: N/A
UniProt Summary: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-1.79
Salubrinal 20μM R07 exp399	-1.72
CCT251545 0.2μM R06 exp271	1.74
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.92
HMS-I2 5μM R06 exp287	2.06
TRAIL 50ng/ml R00 exp36	2.2
TRAIL 5ng/ml R00 exp35	2.43
Actinomycin-D 0.01μM R00 exp4	3.89

Global Fraction of Cell Lines Where Essential: 711/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	25/26
breast	32/33
central nervous system	55/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	72/75
lymphocyte	14/16
ovary	23/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution