SSX1
Gene Information
- Official Symbol: SSX1
- Official Name: SSX family member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6756
- UniProt: Q16384
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013].
- UniProt Summary: Could act as a modulator of transcription.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14335
- Expression level (log2 read counts): -3.08
SSX1 Expression in NALM6 Cells: -3.08
