TNFRSF6B
Gene Information
- Official Symbol: TNFRSF6B
- Official Name: TNF receptor superfamily member 6b
- Aliases and Previous Symbols: N/A
- Entrez ID: 8771
- UniProt: O95407
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011].
- UniProt Summary: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. {ECO:0000269|PubMed:21300286}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4403
- Expression level (log2 read counts): -1.62
TNFRSF6B Expression in NALM6 Cells: -1.62
