UCN3
Gene Information
- Official Symbol: UCN3
- Official Name: urocortin 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 114131
- UniProt: Q969E3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Pfam Domains GO Terms
Pfam Domains
| UCN2 |
GO Terms
| corticotropin-releasing hormone receptor binding |
| corticotropin-releasing hormone receptor 2 binding |
| varicosity |
| positive regulation of membrane potential |
| response to corticosterone |
| response to immobilization stress |
| response to mineralocorticoid |
| axon terminus |
| positive regulation of insulin secretion |
| positive regulation of peptide hormone secretion |
| hormone activity |
| digestion |
| positive regulation of hormone secretion |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| response to glucose |
| response to hexose |
| response to glucocorticoid |
| cAMP-mediated signaling |
| response to monosaccharide |
| response to corticosteroid |
| hormone-mediated signaling pathway |
| cyclic-nucleotide-mediated signaling |
| response to carbohydrate |
| regulation of insulin secretion |
| cellular response to hypoxia |
| response to starvation |
| response to ketone |
| cellular response to decreased oxygen levels |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of peptide hormone secretion |
| cellular response to oxygen levels |
| response to alcohol |
| cellular response to nutrient levels |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| cellular response to extracellular stimulus |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| response to steroid hormone |
| cellular response to external stimulus |
| second-messenger-mediated signaling |
| response to hypoxia |
| response to decreased oxygen levels |
| response to oxygen levels |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| regulation of membrane potential |
| positive regulation of secretion |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| response to nutrient levels |
| response to extracellular stimulus |
| regulation of hormone levels |
| cellular response to hormone stimulus |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| response to lipid |
| response to hormone |
| response to organic cyclic compound |
| positive regulation of transport |
| regulation of protein localization |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| G protein-coupled receptor signaling pathway |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| extracellular space |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9992
- Expression level (log2 read counts): -4.79
Expression Distribution
UCN3 Expression in NALM6 Cells: -4.79
