ZBTB8OS

Entrez Summary: N/A
UniProt Summary: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. {ECO:0000269|PubMed:24870230}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
VE-822 0.04μM R06 exp300	-1.92
Thioridazine 5μM R08 exp530	1.7
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.72
A-366 10μM R03 exp115	1.81
Pimelic-diphenylamide-106 5μM R00 exp28	1.88
Etoposide 1μM R00 exp19	1.97
Nifuroxazide 5μM R03 exp102	2.27
MLN-4924 2μM R00 exp22	2.28

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution