Pfam Domains GO Terms
| positive regulation of myelination |
| positive regulation of oligodendrocyte differentiation |
| regulation of oligodendrocyte differentiation |
| positive regulation of glial cell differentiation |
| oligodendrocyte development |
| regulation of myelination |
| positive regulation of nervous system process |
| positive regulation of gliogenesis |
| oligodendrocyte differentiation |
| regulation of glial cell differentiation |
| glial cell development |
| regulation of gliogenesis |
| regulation of nervous system process |
| glial cell differentiation |
| gliogenesis |
| positive regulation of neurogenesis |
| positive regulation of nervous system development |
| positive regulation of cell development |
| regulation of system process |
| regulation of neurogenesis |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| central nervous system development |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| negative regulation of biosynthetic process |
| neurogenesis |
| cell development |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Temozolomide 200μM R04 exp189 | -2.09 |
| JQ1 0.01μM R03 exp130 | -2.08 |
| UMK57 1μM R01 exp59 | -2.04 |
| UM0130462 0.025 to 0.035μM day4 R05 exp247 | -2.01 |
| Chloramphenicol 2μM R00 exp12 | -1.95 |
| Nocodazole 0.02μM R00 exp23 | -1.93 |
| Pimelic-diphenylamide-106 5μM R00 exp28 | -1.78 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution