ABT1
Gene Information
- Official Symbol: ABT1
- Official Name: activator of basal transcription 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 29777
- UniProt: Q9ULW3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| small-subunit processome assembly |
| endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| rRNA 5-end processing |
| endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| endonucleolytic cleavage involved in rRNA processing |
| endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| ncRNA 5-end processing |
| ribosomal small subunit assembly |
| RNA 5-end processing |
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| cleavage involved in rRNA processing |
| maturation of 5.8S rRNA |
| spinal cord motor neuron differentiation |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| maturation of SSU-rRNA |
| ventral spinal cord development |
| cell differentiation in spinal cord |
| ribosome assembly |
| ribosomal small subunit biogenesis |
| RNA phosphodiester bond hydrolysis, endonucleolytic |
| spinal cord development |
| RNA phosphodiester bond hydrolysis |
| central nervous system neuron differentiation |
| transcription factor complex |
| rRNA processing |
| rRNA metabolic process |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| transcription coactivator activity |
| nucleic acid phosphodiester bond hydrolysis |
| ribosome biogenesis |
| ncRNA processing |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| transcription by RNA polymerase II |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| organelle assembly |
| cellular protein-containing complex assembly |
| nucleolus |
| RNA processing |
| central nervous system development |
| neuron differentiation |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| RNA binding |
| DNA binding |
| generation of neurons |
| protein-containing complex assembly |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1207
- Expression level (log2 read counts): 4.96
Expression Distribution
ABT1 Expression in NALM6 Cells: 4.96
