ARF4
Gene Information
- Official Symbol: ARF4
- Official Name: ADP ribosylation factor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 378
- UniProt: P18085
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Pfam Domains GO Terms
Pfam Domains
| Miro |
| Arf |
| SRPRB |
| Ras |
| G-alpha |
| Gtr1 RagA |
GO Terms
| activation of phospholipase D activity |
| apical protein localization |
| ARF guanyl-nucleotide exchange factor activity |
| dendritic spine development |
| protein ADP-ribosylation |
| epidermal growth factor receptor binding |
| establishment or maintenance of epithelial cell apical/basal polarity |
| protein localization to cilium |
| establishment or maintenance of bipolar cell polarity |
| establishment or maintenance of apical/basal cell polarity |
| response to axon injury |
| epidermal growth factor receptor signaling pathway |
| positive regulation of phospholipase activity |
| Golgi to plasma membrane transport |
| ERBB signaling pathway |
| regulation of phospholipase activity |
| positive regulation of lipase activity |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| vesicle-mediated transport to the plasma membrane |
| ruffle membrane |
| regulation of postsynapse organization |
| regulation of lipase activity |
| post-Golgi vesicle-mediated transport |
| dendrite development |
| learning |
| dendritic spine |
| regulation of reactive oxygen species metabolic process |
| establishment or maintenance of cell polarity |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| learning or memory |
| cognition |
| GTPase activity |
| glutamatergic synapse |
| Golgi vesicle transport |
| GTP binding |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| behavior |
| response to wounding |
| neuron projection development |
| enzyme linked receptor protein signaling pathway |
| protein localization to organelle |
| brain development |
| positive regulation of hydrolase activity |
| head development |
| neuron development |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cell migration |
| central nervous system development |
| Golgi apparatus |
| intracellular protein transport |
| negative regulation of cell death |
| neuron differentiation |
| cell motility |
| localization of cell |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of transcription by RNA polymerase II |
| regulation of hydrolase activity |
| locomotion |
| nervous system process |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| establishment of localization in cell |
| nitrogen compound transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| All-trans-Retinoic-Acid 40μM R07 exp334 | -2.37 |
| Thapsigargin 0.005μM R07 exp407 | -2.09 |
| YM155 0.001μM R08 exp432 | -1.73 |
| Lenalidomide 20μM R07 exp375 | 1.78 |
| Arsenate 40μM R06 exp264 | 1.93 |
| NFN1 1μM R03 exp100 | 1.96 |
| Golgicide-A 4μM R03 exp122 | 5.33 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 151/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 5/28 |
| blood | 7/28 |
| bone | 5/26 |
| breast | 6/33 |
| central nervous system | 10/56 |
| cervix | 0/4 |
| colorectal | 5/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 6/16 |
| kidney | 9/21 |
| liver | 8/20 |
| lung | 14/75 |
| lymphocyte | 1/16 |
| ovary | 5/26 |
| pancreas | 4/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 4/15 |
| prostate | 1/1 |
| skin | 6/24 |
| soft tissue | 1/9 |
| thyroid | 1/2 |
| upper aerodigestive | 4/22 |
| urinary tract | 5/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7314
- Expression level (log2 read counts): 5.76
Expression Distribution
ARF4 Expression in NALM6 Cells: 5.76
