ARL14EP
Gene Information
- Official Symbol: ARL14EP
- Official Name: ADP ribosylation factor like GTPase 14 effector protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 120534
- UniProt: Q8N8R7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014].
- UniProt Summary: Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. {ECO:0000269|PubMed:21458045}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17435
- Expression level (log2 read counts): 5.3
ARL14EP Expression in NALM6 Cells: 5.3
