CCNT1
Gene Information
- Official Symbol: CCNT1
- Official Name: cyclin T1
- Aliases and Previous Symbols: N/A
- Entrez ID: 904
- UniProt: O60563
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377}.
Pfam Domains GO Terms
Pfam Domains
| Cyclin N |
GO Terms
| 7SK snRNA binding |
| negative regulation of mRNA polyadenylation |
| cyclin/CDK positive transcription elongation factor complex |
| negative regulation of mRNA 3-end processing |
| cyclin-dependent protein serine/threonine kinase activator activity |
| RNA polymerase binding |
| positive regulation by host of viral transcription |
| regulation of mRNA polyadenylation |
| negative regulation of mRNA processing |
| regulation of mRNA 3-end processing |
| positive regulation of DNA-templated transcription, elongation |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| cyclin-dependent protein serine/threonine kinase regulator activity |
| positive regulation of cyclin-dependent protein kinase activity |
| positive regulation of viral transcription |
| regulation of DNA-templated transcription, elongation |
| regulation of viral transcription |
| snRNA transcription by RNA polymerase II |
| modification by host of symbiont morphology or physiology |
| snRNA transcription |
| transcription elongation from RNA polymerase II promoter |
| interaction with symbiont |
| negative regulation of mRNA metabolic process |
| DNA-templated transcription, elongation |
| ncRNA transcription |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| positive regulation of viral process |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| regulation of mRNA processing |
| modification of morphology or physiology of other organism |
| regulation of viral process |
| transcription regulatory region DNA binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of mRNA metabolic process |
| transcription factor binding |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of cell cycle |
| chromatin binding |
| protein kinase binding |
| transcription by RNA polymerase II |
| cell division |
| positive regulation of multi-organism process |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of kinase activity |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| positive regulation of transferase activity |
| viral process |
| regulation of multi-organism process |
| symbiotic process |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| nucleolus |
| regulation of kinase activity |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| nucleobase-containing compound biosynthetic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| cell cycle |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 2/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 583
- Expression level (log2 read counts): 7.07
Expression Distribution
CCNT1 Expression in NALM6 Cells: 7.07
