CCT8
Gene Information
- Official Symbol: CCT8
- Official Name: chaperonin containing TCP1 subunit 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 10694
- UniProt: P50990
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.
Pfam Domains GO Terms
Pfam Domains
| Cpn60 TCP1 |
GO Terms
| zona pellucida receptor complex |
| positive regulation of protein localization to Cajal body |
| regulation of protein localization to Cajal body |
| positive regulation of establishment of protein localization to telomere |
| regulation of establishment of protein localization to telomere |
| chaperonin-containing T-complex |
| regulation of establishment of protein localization to chromosome |
| positive regulation of protein localization to chromosome, telomeric region |
| regulation of protein localization to chromosome, telomeric region |
| positive regulation of telomerase RNA localization to Cajal body |
| regulation of telomerase RNA localization to Cajal body |
| pore complex assembly |
| ATPase activity, coupled |
| positive regulation of telomere maintenance via telomerase |
| binding of sperm to zona pellucida |
| positive regulation of telomere maintenance via telomere lengthening |
| toxin transport |
| intermediate filament cytoskeleton |
| positive regulation of telomere maintenance |
| sperm-egg recognition |
| regulation of telomere maintenance via telomerase |
| regulation of telomere maintenance via telomere lengthening |
| positive regulation of DNA biosynthetic process |
| cell-cell recognition |
| cell body |
| positive regulation of protein localization to nucleus |
| regulation of telomere maintenance |
| azurophil granule lumen |
| regulation of DNA biosynthetic process |
| secretory granule lumen |
| regulation of protein localization to nucleus |
| ficolin-1-rich granule lumen |
| unfolded protein binding |
| single fertilization |
| fertilization |
| positive regulation of chromosome organization |
| protein stabilization |
| positive regulation of DNA metabolic process |
| cilium |
| protein folding |
| cell recognition |
| regulation of protein stability |
| cadherin binding |
| microtubule |
| positive regulation of cellular protein localization |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| positive regulation of establishment of protein localization |
| neutrophil degranulation |
| centrosome |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of cellular protein localization |
| myeloid leukocyte activation |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulated exocytosis |
| regulation of establishment of protein localization |
| leukocyte mediated immunity |
| exocytosis |
| sexual reproduction |
| regulation of cellular localization |
| leukocyte activation |
| multi-organism reproductive process |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| reproductive process |
| reproduction |
| ATP binding |
| protein-containing complex assembly |
| protein-containing complex subunit organization |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.424 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 318/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 13/28 |
| blood | 11/28 |
| bone | 12/26 |
| breast | 16/33 |
| central nervous system | 35/56 |
| cervix | 2/4 |
| colorectal | 6/17 |
| esophagus | 3/13 |
| fibroblast | 0/1 |
| gastric | 6/16 |
| kidney | 7/21 |
| liver | 8/20 |
| lung | 25/75 |
| lymphocyte | 8/16 |
| ovary | 9/26 |
| pancreas | 5/24 |
| peripheral nervous system | 5/16 |
| plasma cell | 3/15 |
| prostate | 0/1 |
| skin | 11/24 |
| soft tissue | 5/9 |
| thyroid | 1/2 |
| upper aerodigestive | 13/22 |
| urinary tract | 13/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 661
- Expression level (log2 read counts): 8.4
Expression Distribution
CCT8 Expression in NALM6 Cells: 8.4
