UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Cadherin
Cadherin C
GO Terms
cell-cell adhesion mediated by cadherin
catenin complex
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cytoskeletal protein binding
adherens junction organization
cell-cell adherens junction
cell-cell junction assembly
cell-cell junction organization
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
cell junction organization
cell-cell adhesion via plasma-membrane adhesion molecules
cadherin binding
cell-cell adhesion
cell surface
calcium ion binding
cell morphogenesis
brain development
head development
cellular component morphogenesis
protein homodimerization activity
cell adhesion
biological adhesion
central nervous system development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)