CHERP
Gene Information
- Official Symbol: CHERP
- Official Name: calcium homeostasis endoplasmic reticulum protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 10523
- UniProt: Q8IWX8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}.
Pfam Domains GO Terms
Pfam Domains
| Surp |
| DUF618 |
| G-patch |
GO Terms
| positive regulation of calcineurin-mediated signaling |
| positive regulation of calcineurin-NFAT signaling cascade |
| sarcoplasmic reticulum membrane |
| regulation of calcineurin-mediated signaling |
| regulation of calcineurin-NFAT signaling cascade |
| positive regulation of calcium-mediated signaling |
| release of sequestered calcium ion into cytosol |
| negative regulation of sequestering of calcium ion |
| calcium ion transmembrane import into cytosol |
| calcium ion transport into cytosol |
| cytosolic calcium ion transport |
| regulation of calcium-mediated signaling |
| regulation of sequestering of calcium ion |
| ion channel binding |
| calcium ion transmembrane transport |
| calcium ion transport |
| positive regulation of cytosolic calcium ion concentration |
| divalent metal ion transport |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| divalent inorganic cation transport |
| regulation of cytosolic calcium ion concentration |
| RNA splicing |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| mRNA processing |
| divalent inorganic cation homeostasis |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| negative regulation of cell population proliferation |
| mRNA metabolic process |
| perinuclear region of cytoplasm |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| RNA processing |
| cellular homeostasis |
| ion transmembrane transport |
| positive regulation of intracellular signal transduction |
| chemical homeostasis |
| transmembrane transport |
| ion transport |
| RNA binding |
| regulation of cell population proliferation |
| homeostatic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trametinib 10μM R02 exp83 | -2.06 |
| Docetaxel 0.002μM R01 exp45 | -1.98 |
| Caffeine 2600μM R08 exp463 | -1.88 |
| MS023 2μM R03 exp134 | -1.8 |
| GSK-J4 1-1.25μM to day4 R07 exp363 | -1.73 |
| GSK461364A 0.005μM R03 exp125 | -1.73 |
| Bisphenol F 50μM R08 exp457 | 1.72 |
| Arsenate 40μM R06 exp264 | 1.72 |
| UMK57 1μM R01 exp59 | 1.92 |
| Bafilomycin-A1 0.009μM R08 exp454 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 707/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 26/26 |
| breast | 30/33 |
| central nervous system | 52/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 19/20 |
| lung | 73/75 |
| lymphocyte | 15/16 |
| ovary | 25/26 |
| pancreas | 23/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 905
- Expression level (log2 read counts): 6.87
Expression Distribution
CHERP Expression in NALM6 Cells: 6.87
