CNIH4

Entrez Summary: N/A
UniProt Summary: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750). {ECO:0000269|PubMed:24405750}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.74
Quercetin 20μM R08 exp517	1.77
MS094 2μM R03 exp136	1.86
S-trityl-L-cysteine 0.5μM R05 exp243	1.87
Nifurtimox 1μM R03 exp141	2.03
Golgicide-A 4μM R03 exp122	2.22
VER-155008 3.9μM R06 exp301	2.27

Global Fraction of Cell Lines Where Essential: 612/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	27/28
bone	23/26
breast	29/33
central nervous system	41/56
cervix	4/4
colorectal	14/17
esophagus	11/13
fibroblast	1/1
gastric	15/16
kidney	16/21
liver	14/20
lung	62/75
lymphocyte	11/16
ovary	24/26
pancreas	22/24
peripheral nervous system	13/16
plasma cell	13/15
prostate	1/1
skin	22/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	23/29
uterus	3/5

Expression Distribution