CPLX3
Gene Information
- Official Symbol: CPLX3
- Official Name: complexin 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 594855
- UniProt: Q8WVH0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Positively regulates a late step in synaptic vesicle exocytosis. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Synaphin |
GO Terms
| anchored component of presynaptic active zone membrane |
| photoreceptor ribbon synapse |
| neurotransmitter transmembrane transporter activity |
| regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| anchored component of synaptic vesicle membrane |
| regulation of vesicle fusion |
| insulin secretion |
| SNARE complex |
| terminal bouton |
| syntaxin binding |
| peptide hormone secretion |
| synaptic vesicle exocytosis |
| SNARE binding |
| hormone secretion |
| regulation of synaptic vesicle exocytosis |
| hormone transport |
| neurotransmitter secretion |
| signal release from synapse |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| regulation of neurotransmitter transport |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of regulated secretory pathway |
| protein localization to extracellular region |
| signal release |
| peptide secretion |
| neurotransmitter transport |
| visual perception |
| regulation of exocytosis |
| sensory perception of light stimulus |
| regulation of neurotransmitter levels |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| regulation of hormone levels |
| cell junction |
| regulation of vesicle-mediated transport |
| regulated exocytosis |
| regulation of secretion by cell |
| exocytosis |
| regulation of secretion |
| regulation of cellular localization |
| sensory perception |
| secretion by cell |
| export from cell |
| cell-cell signaling |
| secretion |
| regulation of organelle organization |
| nervous system process |
| protein transport |
| peptide transport |
| amide transport |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R08 exp434 | -1.93 |
| Etoposide 10μM R00 exp20 | -1.77 |
| Nifuroxazide 1μM R01 exp51 | 1.78 |
| HMS-I1 1μM R01 exp46 | 1.87 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2828
- Expression level (log2 read counts): -3.7
Expression Distribution
CPLX3 Expression in NALM6 Cells: -3.7
