CPN1
Gene Information
- Official Symbol: CPN1
- Official Name: carboxypeptidase N subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1369
- UniProt: P15169
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008].
- UniProt Summary: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15506
- Expression level (log2 read counts): -6.6
CPN1 Expression in NALM6 Cells: -6.6
