Pfam Domains GO Terms
| Cullin Nedd8 |
| Cullin |
| Cul4B-RING E3 ubiquitin ligase complex |
| cullin-RING ubiquitin ligase complex |
| UV-damage excision repair |
| histone H2A monoubiquitination |
| nucleotide-excision repair, preincision complex stabilization |
| nucleotide-excision repair, DNA incision, 3-to lesion |
| nucleotide-excision repair, DNA duplex unwinding |
| histone H2A ubiquitination |
| nucleotide-excision repair, DNA damage recognition |
| global genome nucleotide-excision repair |
| Cul4-RING E3 ubiquitin ligase complex |
| nucleotide-excision repair, preincision complex assembly |
| histone monoubiquitination |
| positive regulation of G1/S transition of mitotic cell cycle |
| nucleotide-excision repair, DNA incision, 5-to lesion |
| DNA damage response, detection of DNA damage |
| nucleotide-excision repair, DNA incision |
| histone ubiquitination |
| positive regulation of cell cycle G1/S phase transition |
| damaged DNA binding |
| protein monoubiquitination |
| SCF ubiquitin ligase complex |
| transcription-coupled nucleotide-excision repair |
| positive regulation of mitotic cell cycle phase transition |
| cellular response to UV |
| positive regulation of cell cycle phase transition |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| nucleotide-excision repair |
| DNA duplex unwinding |
| cellular response to light stimulus |
| G1/S transition of mitotic cell cycle |
| DNA geometric change |
| cell cycle G1/S phase transition |
| response to UV |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of mitotic cell cycle |
| regulation of cell cycle G1/S phase transition |
| cellular response to radiation |
| protein-DNA complex assembly |
| positive regulation of protein catabolic process |
| protein-DNA complex subunit organization |
| positive regulation of protein complex assembly |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| positive regulation of cell cycle process |
| ubiquitin protein ligase binding |
| DNA conformation change |
| nucleic acid phosphodiester bond hydrolysis |
| ribosome biogenesis |
| response to light stimulus |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| post-translational protein modification |
| histone modification |
| covalent chromatin modification |
| positive regulation of cell cycle |
| regulation of protein catabolic process |
| regulation of mitotic cell cycle phase transition |
| positive regulation of catabolic process |
| response to radiation |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| ribonucleoprotein complex biogenesis |
| DNA repair |
| positive regulation of cellular component biogenesis |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| neuron projection development |
| protein catabolic process |
| mitotic cell cycle |
| protein ubiquitination |
| detection of stimulus |
| chromatin organization |
| DNA metabolic process |
| regulation of cell cycle process |
| protein modification by small protein conjugation |
| cellular response to DNA damage stimulus |
| neuron development |
| cellular protein-containing complex assembly |
| cellular macromolecule catabolic process |
| regulation of cellular component biogenesis |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| cell cycle process |
| neuron differentiation |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| chromosome organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| proteolysis |
| cell cycle |
| generation of neurons |
| protein-containing complex assembly |
| neurogenesis |
| cell development |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| HMS-I1 10μM R06 exp256 | -2.66 |
| Hydroxyurea 15μM R06 exp289 | -1.92 |
| Vincristine 0.0005μM R04 exp190 | 1.79 |
| Gene | Correlation |
|---|---|
| RRM1 | 0.437 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/26 |
| bone | 0/25 |
| breast | 1/30 |
| central nervous system | 1/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 1/72 |
| lymphocyte | 0/14 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 1/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Expression Distribution