CUX1

Entrez Summary: The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R03 exp143	-1.81
Cerivastatin 0.15μM R05 exp226	-1.77
Chloramphenicol 2μM R00 exp12	-1.75
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.95
FTY720 3μM R08 exp483	1.96
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.08
I-BRD9 4μM R07 exp365	2.39
LY2090314 0.003μM R08 exp500 no dilution day6	2.67
LY2090314 0.003μM R08 exp499	2.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution