DCP1A

Gene Information

Official Symbol: DCP1A
Official Name: decapping mRNA 1A
Aliases and Previous Symbols: N/A
Entrez ID: 55802
UniProt: Q9NPI6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R08 exp439	-2.32
UM0131023 0.05μM R05 exp248	-2.01
EPZ-5676 30μM R05 exp233	-1.84
LB-100 2μM R05 exp210	-1.84
NFN1 0.4μM R03 exp99	-1.84
CB-839 10μM R05 exp224	-1.77
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.74
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.71
ETC-159 50μM R08 exp480	-1.7
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.87

Essentiality in NALM6

Essentiality Rank: 18108
Expression level (log2 read counts): 6.11

Expression Distribution