DCTD
Gene Information
- Official Symbol: DCTD
- Official Name: dCMP deaminase
- Aliases and Previous Symbols: N/A
- Entrez ID: 1635
- UniProt: P32321
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Supplies the nucleotide substrate for thymidylate synthetase.
Pfam Domains GO Terms
Pfam Domains
| dCMP cyt deam 1 |
GO Terms
| dCMP deaminase activity |
| dUMP biosynthetic process |
| dTMP metabolic process |
| dTMP biosynthetic process |
| dUMP metabolic process |
| pyrimidine deoxyribonucleoside monophosphate biosynthetic process |
| pyrimidine deoxyribonucleoside monophosphate metabolic process |
| pyrimidine deoxyribonucleotide biosynthetic process |
| deoxyribonucleoside monophosphate biosynthetic process |
| 2-deoxyribonucleotide biosynthetic process |
| deoxyribose phosphate biosynthetic process |
| deoxyribonucleoside monophosphate metabolic process |
| deoxyribonucleotide biosynthetic process |
| pyrimidine nucleoside monophosphate biosynthetic process |
| pyrimidine nucleoside monophosphate metabolic process |
| pyrimidine deoxyribonucleotide metabolic process |
| nucleobase-containing small molecule interconversion |
| 2-deoxyribonucleotide metabolic process |
| deoxyribose phosphate metabolic process |
| deoxyribonucleotide metabolic process |
| nucleoside monophosphate biosynthetic process |
| pyrimidine nucleotide biosynthetic process |
| pyrimidine-containing compound biosynthetic process |
| pyrimidine nucleotide metabolic process |
| nucleoside monophosphate metabolic process |
| pyrimidine-containing compound metabolic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| carbohydrate derivative biosynthetic process |
| zinc ion binding |
| organophosphate metabolic process |
| carbohydrate derivative metabolic process |
| identical protein binding |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Resveratrol 16μM R03 exp147 | -1.92 |
| ABT-702 5μM R06 exp261 | -1.7 |
| BS-181 20μM R08 exp461 | 1.71 |
| Taxol 0.004μM R03 exp103 | 1.79 |
| Aphidicolin 0.4μM R08 exp440 | 2.72 |
| FBS-Wisent 0.1 R07 exp426 | 3 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.603 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10240
- Expression level (log2 read counts): 6.06
Expression Distribution
DCTD Expression in NALM6 Cells: 6.06
