DNAH17

Gene Information

Official Symbol: DNAH17
Official Name: dynein axonemal heavy chain 17
Aliases and Previous Symbols: N/A
Entrez ID: 8632
UniProt: Q9UFH2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.29
Mdivi-1 15μM R05 exp217	-1.73
Mubritinib 0.2μM R02 exp65	1.72
KU-0063794 3.8μM R02 exp71	1.75
Nicotinamide Riboside 100μM R03 exp139	1.75
Trimetrexate 0.03μM R08 exp535	1.78
IWR1 50μM R08 exp495	2.12
Cannabidiol 13μM R08 exp465	2.38

Essentiality in NALM6

Essentiality Rank: 12539
Expression level (log2 read counts): 2.14

Expression Distribution