Entrez Summary: This gene encodes a member of the Dnaj protein family whose members act as co-chaperones of a partner heat-shock protein by binding to the latter and stimulating ATP hydrolysis. The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis. It may also be involved in post-endocytic transport mechanisms via its associations with other proteins, including the sorting nexin SNX1. Mutations in this gene are associated with Parkinson's disease. [provided by RefSeq, Jun 2016].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
DnaJ
GO Terms
regulation of early endosome to recycling endosome transport
WASH complex
regulation of early endosome to late endosome transport
regulation of cytoplasmic transport
azurophil granule membrane
endosome organization
secretory granule membrane
osteoblast differentiation
early endosome membrane
endosome membrane
receptor-mediated endocytosis
ossification
lysosomal membrane
vesicle organization
regulation of intracellular transport
endomembrane system organization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
regulation of vesicle-mediated transport
endocytosis
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
import into cell
intracellular membrane-bounded organelle
regulated exocytosis
leukocyte mediated immunity
exocytosis
regulation of cellular localization
leukocyte activation
secretion by cell
export from cell
cell activation
immune effector process
secretion
protein transport
peptide transport
amide transport
establishment of protein localization
nitrogen compound transport
regulation of transport
immune response
vesicle-mediated transport
membrane
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)