EIF2AK1
Gene Information
- Official Symbol: EIF2AK1
- Official Name: eukaryotic translation initiation factor 2 alpha kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 27102
- UniProt: Q9BQI3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
GO Terms
| negative regulation of translational initiation by iron |
| negative regulation of hemoglobin biosynthetic process |
| regulation of eIF2 alpha phosphorylation by heme |
| regulation of translational initiation by iron |
| response to iron ion starvation |
| regulation of hemoglobin biosynthetic process |
| regulation of translational initiation by eIF2 alpha phosphorylation |
| eukaryotic translation initiation factor 2alpha kinase activity |
| regulation of translational initiation in response to stress |
| protoporphyrinogen IX metabolic process |
| regulation of translation in response to stress |
| negative regulation of translational initiation |
| macrophage differentiation |
| porphyrin-containing compound metabolic process |
| tetrapyrrole metabolic process |
| acute inflammatory response |
| regulation of translational initiation |
| iron ion homeostasis |
| myeloid leukocyte differentiation |
| negative regulation of translation |
| transition metal ion homeostasis |
| heme binding |
| negative regulation of cellular amide metabolic process |
| protein autophosphorylation |
| response to starvation |
| myeloid cell differentiation |
| protein kinase activity |
| phagocytosis |
| leukocyte differentiation |
| regulation of translation |
| regulation of cellular amide metabolic process |
| cofactor metabolic process |
| response to nutrient levels |
| inflammatory response |
| posttranscriptional regulation of gene expression |
| response to extracellular stimulus |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| metal ion homeostasis |
| immune system development |
| negative regulation of cell population proliferation |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of cellular response to stress |
| ion homeostasis |
| protein homodimerization activity |
| protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| phosphorylation |
| defense response |
| negative regulation of cellular macromolecule biosynthetic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| homeostatic process |
| cellular response to stress |
| negative regulation of gene expression |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 251
- Expression level (log2 read counts): 7.23
Expression Distribution
EIF2AK1 Expression in NALM6 Cells: 7.23
