FAM136A

Entrez Summary: This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 1μM R01 exp51	-1.71
Rapamycin 0.001μM R08 exp429	1.72
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.73
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.78
Azithromycin 100μM R08 exp452	1.83
Curcumin 6.5μM R06 exp277	1.88
Taxol 0.004μM R03 exp103	1.91
BI-6727 0.0125μM R03 exp97	2.05
INK128 0.2μM R02 exp70	2.1

Global Fraction of Cell Lines Where Essential: 35/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	3/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	3/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	0/20
lung	2/75
lymphocyte	3/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	0/5

Expression Distribution