FCHO2
Gene Information
- Official Symbol: FCHO2
- Official Name: FCH and mu domain containing endocytic adaptor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 115548
- UniProt: Q0JRZ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14156
- Expression level (log2 read counts): 2.71
FCHO2 Expression in NALM6 Cells: 2.71
