FDFT1
Gene Information
- Official Symbol: FDFT1
- Official Name: farnesyl-diphosphate farnesyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2222
- UniProt: P37268
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SQS PSY |
GO Terms
| squalene synthase activity |
| farnesyl-diphosphate farnesyltransferase activity |
| ergosterol biosynthetic process |
| ergosterol metabolic process |
| phytosteroid metabolic process |
| phytosteroid biosynthetic process |
| farnesyl diphosphate metabolic process |
| cellular alcohol biosynthetic process |
| cellular alcohol metabolic process |
| cellular lipid biosynthetic process |
| cholesterol biosynthetic process |
| secondary alcohol biosynthetic process |
| regulation of cholesterol biosynthetic process |
| regulation of sterol biosynthetic process |
| sterol biosynthetic process |
| regulation of cholesterol metabolic process |
| regulation of alcohol biosynthetic process |
| regulation of steroid biosynthetic process |
| alcohol biosynthetic process |
| regulation of steroid metabolic process |
| cholesterol metabolic process |
| terpenoid metabolic process |
| steroid biosynthetic process |
| secondary alcohol metabolic process |
| sterol metabolic process |
| isoprenoid metabolic process |
| organic hydroxy compound biosynthetic process |
| regulation of lipid biosynthetic process |
| steroid metabolic process |
| alcohol metabolic process |
| phospholipid metabolic process |
| regulation of lipid metabolic process |
| regulation of small molecule metabolic process |
| organic hydroxy compound metabolic process |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| organophosphate metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| endoplasmic reticulum |
| lipid metabolic process |
| organic cyclic compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 9/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8646
- Expression level (log2 read counts): 7.39
Expression Distribution
FDFT1 Expression in NALM6 Cells: 7.39
