FRY

Entrez Summary: N/A
UniProt Summary: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Celastrol 0.12μM R05 exp225	-2.12
Centrinone 0.5μM R07 exp343	-2.07
Rifampicin 30μM R08 exp430	-2.03
LJH685 5μM R02 exp73	-1.92
Curcumin 6.5μM R06 exp277	-1.87
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.87
Colchicine 0.009μM R05 exp215	-1.76
Vemurafenib 6.6μM R02 exp89	-1.76
Epigallocatechin gallate 20μM R05 exp230	-1.71
WNT3A 44ng/ml R08 exp537	2.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution