HELQ

Entrez Summary: N/A
UniProt Summary: Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross- links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904). {ECO:0000269|PubMed:11751861, ECO:0000269|PubMed:19995904}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-2.98
Rucaparib 6.5μM R08 exp520	-2.46
Nutlin-3A 1.6μM R06 exp294	-2.42
Diepoxybutane 3μM R07 exp354	-2.35
Talazoparib 0.006μM R06 exp299	-2.35
VE-822 0.04μM R06 exp300	-1.88
Ethanol 0.01 R05 exp234	-1.75
Asunaprenir 3μM R07 exp336	1.71
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution