IQGAP3
Gene Information
- Official Symbol: IQGAP3
- Official Name: IQ motif containing GTPase activating protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 128239
- UniProt: Q86VI3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RasGAP C |
| RasGAP |
| CH |
| IQ |
GO Terms
| myosin VI light chain binding |
| positive regulation of mammary gland epithelial cell proliferation |
| regulation of mammary gland epithelial cell proliferation |
| ERK1 and ERK2 cascade |
| Rho GTPase binding |
| lateral plasma membrane |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| activation of MAPK activity |
| cell-cell junction |
| regulation of cell size |
| positive regulation of epithelial cell proliferation |
| calmodulin binding |
| Ras protein signal transduction |
| positive regulation of MAP kinase activity |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| small GTPase mediated signal transduction |
| activation of protein kinase activity |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| MAPK cascade |
| regulation of cellular component size |
| signal transduction by protein phosphorylation |
| regulation of GTPase activity |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| mitotic cell cycle process |
| positive regulation of transferase activity |
| mitotic cell cycle |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| positive regulation of cell population proliferation |
| protein phosphorylation |
| regulation of transferase activity |
| cell cycle process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| phosphorylation |
| cell cycle |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| KU-0063794 3.8μM R02 exp71 | -2.04 |
| Pyronaridine 1μM R06 exp295 | -2.03 |
| proTAME 5μM R04 exp187 | -1.86 |
| Actinomycin-D 0.001μM R00 exp3 | -1.74 |
| Nifuroxazide 1μM R01 exp51 | 2.39 |
| WNT3A 44ng/ml R08 exp537 | 2.53 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12619
- Expression level (log2 read counts): 6.18
Expression Distribution
IQGAP3 Expression in NALM6 Cells: 6.18
