MARK1
Gene Information
- Official Symbol: MARK1
- Official Name: microtubule affinity regulating kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4139
- UniProt: Q9P0L2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12500
- Expression level (log2 read counts): 3.71
MARK1 Expression in NALM6 Cells: 3.71
