MLF1IP
Gene Information
- Official Symbol: CENPU
- Official Name: centromere protein U
- Aliases and Previous Symbols: N/A
- Entrez ID: 79682
- UniProt: Q71F23
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8109
- Expression level (log2 read counts): 6.51
MLF1IP Expression in NALM6 Cells: 6.51
