MYPN
Gene Information
- Official Symbol: MYPN
- Official Name: myopalladin
- Aliases and Previous Symbols: N/A
- Entrez ID: 84665
- UniProt: Q86TC9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
- UniProt Summary: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6571
- Expression level (log2 read counts): 0.24
MYPN Expression in NALM6 Cells: 0.24
