NAV3
Gene Information
- Official Symbol: N/AV3
- Official Name: neuron navigator 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 89795
- UniProt: Q8IVL0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May regulate IL2 production by T-cells. May be involved in neuron regeneration. {ECO:0000269|PubMed:16166283}.
Pfam Domains GO Terms
Pfam Domains
| CH |
GO Terms
| positive regulation of invadopodium disassembly |
| regulation of invadopodium disassembly |
| microtubule end |
| negative regulation of interleukin-2 production |
| nuclear outer membrane |
| negative regulation of microtubule depolymerization |
| regulation of microtubule depolymerization |
| positive regulation of microtubule polymerization |
| positive regulation of microtubule polymerization or depolymerization |
| negative regulation of microtubule polymerization or depolymerization |
| regulation of microtubule polymerization |
| regulation of interleukin-2 production |
| negative regulation of protein depolymerization |
| negative regulation of protein complex disassembly |
| regulation of microtubule polymerization or depolymerization |
| regulation of protein depolymerization |
| regulation of protein complex disassembly |
| positive regulation of protein polymerization |
| negative regulation of supramolecular fiber organization |
| negative regulation of cytoskeleton organization |
| regulation of microtubule cytoskeleton organization |
| positive regulation of supramolecular fiber organization |
| positive regulation of cytoskeleton organization |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| microtubule binding |
| positive regulation of protein complex assembly |
| negative regulation of cell migration |
| negative regulation of cytokine production |
| negative regulation of cell motility |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regulation of supramolecular fiber organization |
| negative regulation of organelle organization |
| positive regulation of cell projection organization |
| regulation of protein complex assembly |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| positive regulation of organelle organization |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| regulation of cell migration |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| ATP binding |
| neurogenesis |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| A-366 10μM R03 exp115 | 1.74 |
| Chlorpromazine 10μM R07 exp344 | 1.74 |
| Epothilone-B 0.0015μM R05 exp231 | 1.77 |
| YM155 0.001μM R08 exp432 | 1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3926
- Expression level (log2 read counts): 3.48
Expression Distribution
NAV3 Expression in NALM6 Cells: 3.48
