Pfam Domains GO Terms
| CBFD NFYB HMF |
| Histone |
| CCAAT-binding factor complex |
| regulation of cholesterol biosynthetic process |
| regulation of sterol biosynthetic process |
| protein-DNA complex |
| regulation of cholesterol metabolic process |
| RNA polymerase II transcription factor complex |
| regulation of alcohol biosynthetic process |
| regulation of steroid biosynthetic process |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| regulation of steroid metabolic process |
| regulation of lipid biosynthetic process |
| transcription regulatory region DNA binding |
| protein folding |
| transcription coactivator activity |
| transcription factor binding |
| regulation of lipid metabolic process |
| regulation of small molecule metabolic process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| protein heterodimerization activity |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| DNA-binding transcription factor activity |
| positive regulation of transcription by RNA polymerase II |
| DNA binding |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Gene | Correlation |
|---|---|
| NFYB | 0.452 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 13/28 |
| blood | 11/28 |
| bone | 7/25 |
| breast | 16/33 |
| central nervous system | 19/56 |
| cervix | 3/4 |
| colorectal | 11/17 |
| esophagus | 8/13 |
| fibroblast | 1/1 |
| gastric | 5/15 |
| kidney | 7/21 |
| liver | 9/20 |
| lung | 44/75 |
| lymphocyte | 3/14 |
| ovary | 11/26 |
| pancreas | 14/24 |
| peripheral nervous system | 5/16 |
| plasma cell | 5/15 |
| prostate | 0/1 |
| skin | 10/24 |
| soft tissue | 3/7 |
| thyroid | 1/2 |
| upper aerodigestive | 13/22 |
| urinary tract | 9/29 |
| uterus | 3/5 |
Expression Distribution