NXF1

Entrez Summary: N/A
UniProt Summary: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:9660949}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	-1.94
DABN racemic mixture R03 exp93	-1.79
Ethanol 0.003 R08 exp437	1.7
JQ1 0.01μM R03 exp130	1.73
Disulfiram 4.3μM R06 exp281	1.74
Metformin 100 to 150μM on day4 R04 exp170	1.8
L-74142 5μM R03 exp131	1.83
SB203580 25μM R03 exp149	1.92
Rucaparib 6.5μM R08 exp520	2.03
Betulinic acid 10 to 15μM on day4 R05 exp222	2.08
Momordin-Ic 10μM R08 exp506	2.3
Cisplatin 0.35μM R06 exp273	2.33

Global Fraction of Cell Lines Where Essential: 523/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	22/28
blood	25/28
bone	13/26
breast	24/33
central nervous system	38/56
cervix	3/4
colorectal	12/17
esophagus	10/13
fibroblast	0/1
gastric	11/16
kidney	12/21
liver	14/20
lung	49/75
lymphocyte	11/16
ovary	21/26
pancreas	18/24
peripheral nervous system	11/16
plasma cell	12/15
prostate	1/1
skin	20/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	14/22
urinary tract	20/29
uterus	4/5

Expression Distribution