OMA1

Entrez Summary: N/A
UniProt Summary: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {ECO:0000250|UniProtKB:Q9D8H7, ECO:0000269|PubMed:20038677}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1μM R07 exp362	-2.04
Vitamin-D3 40μM R08 exp536	1.76
BI-D1870 3.15μM R02 exp66	1.78
Calcium Ionophore 0.4μM R07 exp342	1.78
Rapamycin 1μM R00 exp29	1.8
Dimethyl-Sulfoxide 1pc R03 exp120	1.82
Bisphenol A 100μM R06 exp269	1.84
HMS-I2 10μM R06 exp288	1.97
LLY-283 2.6μM R06 exp290	2.27
iCRT14 30μM R08 exp492	2.95
All-trans-Retinoic-Acid 40μM R07 exp334	3.25
UM0129480 7μM R02 exp85	3.25
Oligomycin-A 2μM R00 exp25	8.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution