PHF8

Entrez Summary: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.46
Dimethyloxaloylglycine 100μM R05 exp229	-2.04
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.98
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.96
Vemurafenib 6.6μM R02 exp89	-1.95
BVD-523 15μM R02 exp67	-1.83
TRAIL 5ng/ml R00 exp35	-1.78
Diepoxybutane 3μM R07 exp354	-1.77
HMS-I2 10μM R06 exp288	1.7
THZ1 0.06μM R08 exp531	1.73
VER-155008 3.9μM R06 exp301	1.79
ABT-702 5μM R07 exp318	1.97
QNZ 0.01μM R08 exp439	2.2

Gene	Correlation
HGC6.3	0.46
UBE2Q1	0.426

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution