UBE2Q1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 10μM R00 exp20	-2.47
Diepoxybutane 3μM R07 exp354	-2.35
Rotenone 20μM R00 exp34	-2.18
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2
Etoposide 1μM R00 exp19	-2
Hydroxyurea 100μM R07 exp329	-1.91
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.71
Nicotinamide 2000μM R01 exp50	1.7
LLY-283 2.6μM R06 exp290	1.76
Nifuroxazide 5μM R03 exp102	1.78
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.8
Nicotine 3000μM R08 exp510	1.85
VER-155008 3.9μM R06 exp301	2.03
Cytochalasin-B 5μM R07 exp349	2.28
Ethanol 0.01 R05 exp234	2.59
Latrunculin-B 10μM R07 exp374	3
THZ531 0.225μM R08 exp444	3.68

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

prolactin secretion
suckling behavior
mating behavior
reproductive behavior
mating
embryo implantation
ubiquitin conjugating enzyme activity
peptide hormone secretion
multi-organism behavior
hormone secretion
filopodium
hormone transport
feeding behavior
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
fertilization
peptide secretion
female pregnancy
multi-multicellular organism process
reproductive system development
regulation of hormone levels
behavior
protein ubiquitination
protein modification by small protein conjugation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
protein modification by small protein conjugation or removal
multi-organism reproductive process
secretion by cell
export from cell
cell-cell signaling
secretion
reproductive process
reproduction
ATP binding
protein transport
peptide transport