E2F2

Gene Information

Official Symbol: E2F2
Official Name: E2F transcription factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 1870
UniProt: Q14209
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	1.79
Phenformin 20μM R05 exp212	1.83
THZ531 0.225μM R08 exp444	1.94
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.05
GSK626616 14μM R08 exp485	2.21
Olaparib 4μM R08 exp512	2.38
Arsenate 40μM R06 exp264	2.48
MLN-4924 0.2μM R00 exp21	2.55
Cytochalasin-B 5μM R07 exp349	2.87
Methotrexate 0.01μM R08 exp501	3.47
Aminopterin 0.005μM R07 exp335	3.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9045
Expression level (log2 read counts): 8.58

Expression Distribution

Gene	Correlation
TFDP1	0.456
CTNNBL1	0.402
UBE2Q1	0.401

lens fiber cell apoptotic process
negative regulation of sprouting angiogenesis
epithelial cell apoptotic process
proximal promoter sequence-specific DNA binding
intrinsic apoptotic signaling pathway by p53 class mediator
regulation of sprouting angiogenesis
RNA polymerase II transcription factor complex
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
signal transduction by p53 class mediator
intrinsic apoptotic signaling pathway
protein dimerization activity
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
apoptotic signaling pathway
regulation of angiogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
regulation of vasculature development
transcription factor binding
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
apoptotic process
negative regulation of developmental process
programmed cell death
regulation of anatomical structure morphogenesis
cell death
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II