PIDD
Gene Information
- Official Symbol: PIDD1
- Official Name: p53-induced death domain protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55367
- UniProt: Q9HB75
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Death |
| Peptidase S68 |
| ZU5 |
| LRR 4 |
GO Terms
| volume-sensitive anion channel activity |
| ion channel complex |
| death receptor binding |
| protein autoprocessing |
| extrinsic apoptotic signaling pathway via death domain receptors |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| G1 DNA damage checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| endopeptidase activity |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitotic DNA damage checkpoint |
| extrinsic apoptotic signaling pathway |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| DNA damage checkpoint |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| DNA integrity checkpoint |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of NF-kappaB transcription factor activity |
| mitotic cell cycle checkpoint |
| protein processing |
| inorganic anion transport |
| regulation of cell cycle G1/S phase transition |
| positive regulation of endopeptidase activity |
| positive regulation of peptidase activity |
| cell cycle checkpoint |
| negative regulation of mitotic cell cycle phase transition |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| protein maturation |
| negative regulation of cell cycle phase transition |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of DNA-binding transcription factor activity |
| anion transmembrane transport |
| apoptotic signaling pathway |
| positive regulation of cell cycle process |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| positive regulation of proteolysis |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| regulation of DNA-binding transcription factor activity |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| negative regulation of cell cycle |
| anion transport |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| mitotic cell cycle |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of cell cycle process |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| ion transmembrane transport |
| Golgi apparatus |
| negative regulation of cell death |
| cell cycle process |
| programmed cell death |
| cell death |
| regulation of cell cycle |
| proteolysis |
| regulation of hydrolase activity |
| transmembrane transport |
| cell cycle |
| ion transport |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of intracellular signal transduction |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NFN1 0.1μM R01 exp49 | 1.7 |
| RO-3307 4.7μM R02 exp80 | 2.7 |
| Cytochalasin-B 5μM R07 exp349 | 5.81 |
| Latrunculin-B 10μM R07 exp374 | 6.5 |
| Tozasertib 0.1μM R07 exp414 | 6.68 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CRADD | 0.758 |
| C2CD3 | 0.722 |
| KIAA0753 | 0.707 |
| ODF2 | 0.693 |
| C16orf59 | 0.659 |
| CASP2 | 0.655 |
| ANKRD26 | 0.654 |
| PIBF1 | 0.653 |
| OFD1 | 0.644 |
| C14orf80 | 0.637 |
| CCDC41 | 0.621 |
| NIN | 0.609 |
| CEP120 | 0.606 |
| CEP76 | 0.588 |
| CEP128 | 0.577 |
| TUBD1 | 0.563 |
| FOPNL | 0.557 |
| RTTN | 0.554 |
| SCLT1 | 0.547 |
| TUBE1 | 0.512 |
| CEP78 | 0.511 |
| CEP44 | 0.494 |
| HYLS1 | 0.493 |
| IPP | 0.435 |
| PPP1R35 | 0.432 |
| CEP152 | 0.411 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3112
- Expression level (log2 read counts): 5.24
Expression Distribution
PIDD Expression in NALM6 Cells: 5.24
