PRDX1

Entrez Summary: N/A
UniProt Summary: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-4.74
Olaparib 4μM R08 exp512	-4.38
Menadione 5μM R06 exp292	-4.21
Cryptotanshinone 12μM R05 exp227	-3.77
Rucaparib 6.5μM R08 exp520	-3.74
Nifuroxazide 5μM R03 exp102	-3.53
YM155 0.001μM R08 exp432	-3.34
Nifuroxazide 1μM R01 exp51	-2.77
UM0131023 0.05μM R05 exp248	-2.15
Celastrol 0.12μM R05 exp225	-1.89
Talazoparib 0.006μM R06 exp299	-1.83
Deguelin 0.15μM R05 exp209	-1.81
A-395N 10μM R05 exp219	-1.76
Ribavirin 10 to 15μM on day4 R04 exp160	-1.75
Tanespimycin 14μM R08 exp527	-1.72
Dynasore 7μM R08 exp436	1.72
BI-6727 0.0125μM R03 exp97	1.82
Thimerosal 0.85μM R08 exp529	2.15
Tubacin 1.6μM R07 exp416	2.75

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution