PUS7

Gene Information

Official Symbol: PUS7
Official Name: pseudouridine synthase 7
Aliases and Previous Symbols: N/A
Entrez ID: 54517
UniProt: Q96PZ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 1μM R03 exp100	-2.76
NFN1 0.4μM R03 exp99	-2.61
Dorsomorphin 5μM R07 exp357	-2.58
Bortezomib 0.005μM R00 exp6	-2.4
Genistein 15μM R07 exp360	-2.21
Vemurafenib 6.6μM R08 exp434	-2.17
Methotrexate 0.01μM R08 exp501	-2.14
UM0125461 0.74μM R02 exp84	-2.06
Aminopterin 0.005μM R07 exp335	-2.01
Tozasertib 0.1μM R07 exp414	-1.98
BRD2 inhibitor II 20μM R07 exp341	-1.83
HMS-I1 10μM R06 exp256	-1.78
HMS-I2 10μM R06 exp288	2.04
Vincristine 0.0005μM R04 exp190	2.17

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15027
Expression level (log2 read counts): 6.08

Expression Distribution