Pfam Domains GO Terms
| Arm |
| V-ATPase H N |
| negative regulation of endoplasmic reticulum calcium ion concentration |
| positive regulation of mitochondrial calcium ion concentration |
| myosin filament assembly |
| myosin filament organization |
| vascular smooth muscle contraction |
| endoplasmic reticulum calcium ion homeostasis |
| mitochondrial calcium ion homeostasis |
| vasoconstriction |
| negative regulation of blood vessel diameter |
| smooth muscle contraction |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| vascular process in circulatory system |
| muscle contraction |
| GTPase activator activity |
| muscle system process |
| blood circulation |
| circulatory system process |
| positive regulation of GTPase activity |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| cellular metal ion homeostasis |
| actin filament-based process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| cellular protein-containing complex assembly |
| cellular homeostasis |
| endoplasmic reticulum |
| cytoskeleton organization |
| chemical homeostasis |
| mitochondrion |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| protein-containing complex assembly |
| homeostatic process |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| system process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Gene | Correlation |
|---|---|
| RRM1 | 0.496 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution