RHOC
Gene Information
- Official Symbol: RHOC
- Official Name: ras homolog family member C
- Aliases and Previous Symbols: N/A
- Entrez ID: 389
- UniProt: P08134
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}.
Pfam Domains GO Terms
Pfam Domains
| Ras |
| Arf |
| Miro |
GO Terms
| skeletal muscle satellite cell migration |
| cell division site |
| positive regulation of protein homooligomerization |
| establishment or maintenance of actin cytoskeleton polarity |
| establishment or maintenance of cytoskeleton polarity |
| regulation of protein homooligomerization |
| positive regulation of protein oligomerization |
| wound healing, spreading of cells |
| epiboly involved in wound healing |
| epiboly |
| stereocilium |
| regulation of protein oligomerization |
| apical junction assembly |
| morphogenesis of an epithelial sheet |
| positive regulation of stress fiber assembly |
| cleavage furrow |
| positive regulation of actin filament bundle assembly |
| actin filament bundle assembly |
| actin filament bundle organization |
| mitotic cytokinesis |
| positive regulation of lipase activity |
| Rho protein signal transduction |
| regulation of stress fiber assembly |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| cytoskeleton-dependent cytokinesis |
| regulation of lipase activity |
| cytokinesis |
| cell-cell junction assembly |
| cell cortex |
| cell-cell junction organization |
| regulation of cell shape |
| cell junction assembly |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| cell junction organization |
| positive regulation of cytoskeleton organization |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| actin filament organization |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| small GTPase mediated signal transduction |
| GTPase activity |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| regulation of actin filament-based process |
| GTP binding |
| morphogenesis of an epithelium |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| protein kinase binding |
| wound healing |
| regulation of cell morphogenesis |
| cell division |
| actin cytoskeleton organization |
| positive regulation of cell migration |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of locomotion |
| tissue morphogenesis |
| actin filament-based process |
| response to wounding |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| mitotic cell cycle |
| intracellular membrane-bounded organelle |
| positive regulation of hydrolase activity |
| regulation of cell migration |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| cell cycle process |
| positive regulation of intracellular signal transduction |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| cytoskeleton organization |
| epithelium development |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| regulation of organelle organization |
| locomotion |
| G protein-coupled receptor signaling pathway |
| cell cycle |
| positive regulation of catalytic activity |
| movement of cell or subcellular component |
| positive regulation of signal transduction |
| intracellular signal transduction |
| tissue development |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Genistein 15μM R07 exp360 | -1.93 |
| Doxycycline 10μM R00 exp18 | -1.81 |
| Alda-1 10μM R06 exp262 | -1.77 |
| Selumetinib 20μM R02 exp81 | -1.73 |
| ABT-702 0.1μM R06 exp260 | -1.72 |
| SB203580 25μM R03 exp149 | 1.7 |
| CAY10603 0.55μM R08 exp467 | 1.85 |
| Trientine 500μM R08 exp534 | 1.91 |
| Disulfiram 4.3μM R06 exp281 | 2 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7833
- Expression level (log2 read counts): 3.21
Expression Distribution
RHOC Expression in NALM6 Cells: 3.21
