RIT1
Gene Information
- Official Symbol: RIT1
- Official Name: Ras like without CAAX 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6016
- UniProt: Q92963
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
- UniProt Summary: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. {ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10667
- Expression level (log2 read counts): 5.03
RIT1 Expression in NALM6 Cells: 5.03
