RPS6
Gene Information
- Official Symbol: RPS6
- Official Name: ribosomal protein S6
- Aliases and Previous Symbols: N/A
- Entrez ID: 6194
- UniProt: P62753
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S6e |
GO Terms
| activation-induced cell death of T cells |
| T cell proliferation involved in immune response |
| mammalian oogenesis stage |
| small ribosomal subunit |
| T cell apoptotic process |
| lymphocyte apoptotic process |
| leukocyte apoptotic process |
| TOR signaling |
| erythrocyte development |
| T cell homeostasis |
| T cell proliferation |
| polysome |
| cytosolic small ribosomal subunit |
| T cell differentiation in thymus |
| lymphocyte homeostasis |
| myeloid cell development |
| T cell activation involved in immune response |
| cytoplasmic ribonucleoprotein granule |
| ribosomal small subunit biogenesis |
| leukocyte homeostasis |
| cell body |
| oogenesis |
| erythrocyte differentiation |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| erythrocyte homeostasis |
| SRP-dependent cotranslational protein targeting to membrane |
| leukocyte proliferation |
| cotranslational protein targeting to membrane |
| myeloid cell homeostasis |
| protein targeting to ER |
| lymphocyte activation involved in immune response |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| viral gene expression |
| female gamete generation |
| T cell differentiation |
| protein localization to endoplasmic reticulum |
| translational initiation |
| placenta development |
| mitotic cell cycle checkpoint |
| ribonucleoprotein complex |
| gastrulation |
| protein targeting to membrane |
| structural constituent of ribosome |
| glucose homeostasis |
| carbohydrate homeostasis |
| cell cycle checkpoint |
| nuclear-transcribed mRNA catabolic process |
| homeostasis of number of cells |
| rRNA processing |
| mRNA catabolic process |
| myeloid cell differentiation |
| rRNA metabolic process |
| T cell activation |
| lymphocyte differentiation |
| RNA catabolic process |
| germ cell development |
| establishment of protein localization to membrane |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| ribosome biogenesis |
| negative regulation of mitotic cell cycle |
| leukocyte differentiation |
| cellular process involved in reproduction in multicellular organism |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| lymphocyte activation |
| ncRNA processing |
| peptide biosynthetic process |
| dendrite |
| reproductive structure development |
| reproductive system development |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| protein kinase binding |
| ncRNA metabolic process |
| organic cyclic compound catabolic process |
| protein localization to membrane |
| amide biosynthetic process |
| peptide metabolic process |
| cell population proliferation |
| hemopoiesis |
| embryonic morphogenesis |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| hematopoietic or lymphoid organ development |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| developmental process involved in reproduction |
| mitotic cell cycle |
| gamete generation |
| mRNA metabolic process |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| nucleolus |
| RNA processing |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| apoptotic process |
| leukocyte activation |
| embryo development |
| intracellular protein transport |
| negative regulation of cell death |
| multi-organism reproductive process |
| cell cycle process |
| endoplasmic reticulum |
| macromolecule catabolic process |
| programmed cell death |
| cell activation |
| cell death |
| immune effector process |
| chemical homeostasis |
| regulation of cell cycle |
| cell cycle |
| RNA binding |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cell development |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| immune response |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 738/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 82
- Expression level (log2 read counts): 9.99
Expression Distribution
RPS6 Expression in NALM6 Cells: 9.99
