SDK1

Entrez Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].
UniProt Summary: Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q8AV58}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-1.73
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.71
Centrinone 0.5μM R07 exp343	1.7
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.81
Vinblastine 0.015μM R05 exp208	1.93
SB743921 0.001μM R05 exp244	1.98
HMS-I1 10μM R06 exp256	2.17
Rotenone 2μM R00 exp33	2.2
Nocodazole 0.1μM R03 exp94	2.49
R-DABN 8μM R03 exp111	3.13
DABN racemic mixture R03 exp93	3.42
Nocodazole 0.2μM R00 exp24	4.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution