SIN3B

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. {ECO:0000250|UniProtKB:Q62141}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.005μM R03 exp125	-2.65
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2.28
Pomalidomide 20μM R07 exp391	-2.18
Caffeine 2600μM R08 exp463	-2.06
CHIR-124 0.04μM R06 exp272	-2.05
ONC212 0.15μM R08 exp513	1.72
Ammonium tetrathiomolybdate 10μM R08 exp448	1.77
PU-H71 1μM R08 exp515	1.81
TIC10 10μM R08 exp532	1.81
JQ1 0.8μM R08 exp435	1.85

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution