SLN

Entrez Summary: N/A
UniProt Summary: Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQD6, ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pterostilbene 16μM R02 exp78	-1.86
Pyronaridine 1μM R06 exp295	-1.86
GSK461364A 0.1μM R03 exp126	1.7
SGC2096 2.6μM R03 exp153	1.72
Resveratrol 16μM R03 exp147	1.73
MLN-4924 0.2μM R00 exp21	1.74
AICAR 240μM R03 exp116	1.76
All-trans-Retinoic-Acid 40μM R07 exp334	1.92
Bleomycin 5μM R08 exp459	1.94
Q15 1 to 2μM on day4 R04 exp164	2.33

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution